

Nothing major as far as I can tell. Here’s an overview via SuperUser. KeePassXC might be a better option for some use cases if you’re mostly not on Windows as it does not require .NET. Note that “KeePassXC does not support plugins at the moment and probably never will”, but it does have built-in support for some things you might want a plugin for in KeePass2.
It does indeed. My job includes writing and deploying .NET apps on multiple platforms, and it works fine for me.
But some people prefer not to use .NET when comparable native options are available, so they might prefer KeePassXC.