FYI, every melatonin supplement is way too high of a dose and is completely saturating your melatonin receptors, leading to tolerance and dependency.
Your body is not producing more than .5mg of melatonin naturally, so taking a 5mg supplement is far too much. And they sell 15-20mg too. If you can find 1mg that’s best; but what’s even better in the long run is not using it!
Bioavailability of oral melatonin is very poor though. IIRC it’s about 10%, so that 5mg sounds about right.
That’s a great point! You’re definitely right. I’m seeing somewhere between 10-30% depending on patient population.
That being said, since we are naturally releasing .5mg, another .5mg is already double the normal concentration.
Another major point of consideration though would be formulation, as that is going to have a large effect on the half life of the dose in your system. Even if bioavailability is around physiological concentration at 5mg, the duration of the exposure being much longer than the time it takes for natural release would still have negative impact.
All this being said, definitely never a reason to go above 5mg
